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TBCD (基因名), Tubulin-specific chaperone D (蛋白名), tbcd_bovin.
产品名称:

Bovine TBCD/ Tubulin-specific chaperone D ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Beta-tubulin cofactor D, Tubulin-folding cofactor D

检测方法:
ELISA
特异性:
Natural and recombinant bovine Tubulin-specific chaperone D
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TBCD ELISA Kit
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Bovine TBCD ELISA Kit
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通用注释


亚单元:
Interacts with ARL2; interaction is enhanced with the GDP-bound form of ARL2. Does not interact with ARL3, ARL4A and ARL4D. Interacts with beta tubulin (By similarity). Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with PPP2CB. Interacts with ARL2.


功能:
Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.


亚细胞位置:
Cell junction Tight junction Lateral cell membrane Cytoplasm Cell junction Adherens junction Localized in cell-cell contacts.


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