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TBC1D7 (基因名), TBC1 domain family member 7 (蛋白名), tbcd7_bovin.
产品名称:

Bovine TBC1D7/ TBC1 domain family member 7 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant bovine TBC1 domain family member 7
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TBC1D7 ELISA Kit
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Bovine TBC1D7 ELISA Kit
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通用注释


亚单元:
Component of the TSC-TBC complex (also named Rhebulator complex), composed of the TSC1-TSC2 heterodimer and TBC1D7. Interacts with TSC1 (via C-terminal half of the coiled-coil domain).


功能:
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.


亚细胞位置:
Cytoplasmic vesicle Localizes in the cytoplasmic vesicles of the endomembrane in association with TSC1-TSC2 complex.


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