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TAP2 (基因名), Antigen peptide transporter 2 (蛋白名), tap2_human.
产品名称:

Human TAP2/ Antigen peptide transporter 2 ELISA Kit
抗原肽转运蛋白2

货号:

E10018h

商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family B member 3, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter TAP2, Peptide transporter involved in antigen processing 2, Really interesting new gene 11 protein, PSF-2, APT2, ABCB3, PSF2, RING11, Y1

检测方法:
ELISA
实验类型:
Competitive
检测范围:
0.625-40ng/mL
灵敏度:
0.307ng/mL
特异性:
Natural and recombinant human Antigen peptide transporter 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human TAP2 ELISA Kit
规格 & 价格: cart
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Human TAP2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

90-99%

92-104%

100-108%

104-115%

EDTA plasma(n=5)

105-117%

108-118%

106-116%

95-103%

heparin plasma(n=5)

95-106%

 

103-115%

87-97%

95-108%

 

通用注释


亚单元:
Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Interacts with herpes simplex virus ICP47 (PubMed:7760936).


功能:
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein The transmembrane segments seem to form a pore in the membrane.


该产品尚未在任何出版物中被引用。
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