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TAOK1 (基因名), Serine/threonine-protein kinase TAO1 (蛋白名), taok1_human.
产品名称:

Human TAOK1/ Serine/threonine-protein kinase TAO1 ELISA Kit
TAO激酶1

货号:

E2238h

商标:
EIAab®
监管等级:
别名:

Kinase from chicken homolog B, MARK Kinase, Prostate-derived sterile 20-like kinase 2, Thousand and one amino acid protein kinase 1, hKFC-B, MARKK, PSK-2, TAOK1, KIAA1361, MAP3K16, MARKK

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/ml
灵敏度:
39pg/mL
特异性:
Natural and recombinant human Serine/threonine-protein kinase TAO1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human TAOK1 ELISA Kit
规格 & 价格: cart
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Human TAOK1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤8.1%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤10.4%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

92

86-98

Plasma

94

88-100

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

101-110%

106-118%

109-119%

107-117%

EDTA plasma(n=5)

80-89%

97-106%

98-107%

89-101%

heparin plasma(n=5)

105-115%

 

91-101%

107-116%

105-114%

 

通用注释


亚单元:
Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with MAP3K7.


功能:
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.


亚细胞位置:
Cytoplasm


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