EIAab
首页  >  酶联免疫试剂盒  >  Pig TMEM173 ELISA Kit
TMEM173 (基因名), Stimulator of interferon genes protein (蛋白名), sting_pig.
产品名称:

Pig TMEM173/ Stimulator of interferon genes protein ELISA Kit

货号:

E16244p

商标:
EIAab®
监管等级:
别名:

Transmembrane protein 173, poSTING, STING

检测方法:
ELISA
特异性:
Natural and recombinant pig Stimulator of interferon genes protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Immunology
Pig TMEM173 ELISA Kit
规格 & 价格: cart
×
Pig TMEM173 ELISA Kit
邮箱 *
消息 *
Please 登录.
产品说明书
在线询价


通用注释


亚单元:
Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta (By similarity). Interacts with IFIT1 and IFIT2.


功能:
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein Mitochondrion outer membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cytoplasm Perinuclear region Cytoplasm In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.


该产品尚未在任何出版物中被引用。
关闭
Sample Data
关闭
Sample Data
关闭
Sample Data
用户中心 close
购物车 close
我的收藏 close
我的足迹 close
清除
产品对比 close
用户中心
购物车
我的收藏
我的足迹
产品对比
回到顶部
通知
new 咨询
规格 数量 单价 (¥) 小计 1 (¥)
小计 2:
triangle
规格 数量 单价 (¥)
你想做我们的代理并得到更低的折扣吗?
请联系我们:
电话:027-59234612(+86)
传真:027-59234610(+86)
邮箱:sales@eiaab.com