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Slc26a5 (基因名), Prestin (蛋白名), s26a5_rat.
产品名称:

Rat Slc26a5/ Prestin ELISA Kit
前列素

货号:

E15288r

商标:
EIAab®
监管等级:
别名:

Solute carrier family 26 member 5, Pres

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
15.6-1000pg/mL
灵敏度:
7.8pg/mL
特异性:
Natural and recombinant rat Prestin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat Slc26a5 ELISA Kit
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Rat Slc26a5 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
N/A


功能:
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.


亚细胞位置:
Cell membrane Multi-pass membrane protein Lateral wall of outer hair cells.


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