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Rock2 (基因名), Rho-associated protein kinase 2 (蛋白名), rock2_rat.
产品名称:

Rat Rock2/ Rho-associated protein kinase 2 ELISA Kit
Rho相关蛋白激酶2

货号:

E1852r

商标:
EIAab®
监管等级:
别名:

Rho-associated, coiled-coil-containing protein kinase 2, Rho-associated, coiled-coil-containing protein kinase II, RhoA-binding kinase 2, p150 ROK-alpha, p164 ROCK-2, ROCK-II, ROKalpha

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
1.56-100ng/mL
灵敏度:
0.87ng/mL
特异性:
Natural and recombinant rat Rho-associated protein kinase 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Rat Rock2 ELISA Kit
规格 & 价格: cart
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Rat Rock2 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homodimer (By similarity). Interacts with CHORDC1, PPP1R12A, SORL1, EP300 and BRCA2 (By similarity). Interacts with NPM1 and this interaction enhances its activity (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC and IRS1. Interacts with RAF1.


功能:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.


亚细胞位置:
Cytoplasm Cell membrane Peripheral membrane protein Nucleus Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasmic, and associated with actin microfilaments and the plasma membrane.


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