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RIF1 (基因名), Telomere-associated protein RIF1 (蛋白名), rif1_chick.
产品名称:

Chicken RIF1/ Telomere-associated protein RIF1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Rap1-interacting factor 1 homolog

检测方法:
ELISA
特异性:
Natural and recombinant chicken Telomere-associated protein RIF1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Chicken RIF1 ELISA Kit
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Chicken RIF1 ELISA Kit
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通用注释


亚单元:
Interacts with TP53BP1 (when phosphorylated by ATM).


功能:
Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333306). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).


亚细胞位置:
Nucleus Chromosome Chromosome Telomere Cytoplasm Cytoskeleton Spindle Following interaction with TP53BP1, recruited to sites of DNA damage, such as double-strand DNA breaks (DSBs).


该产品尚未在任何出版物中被引用。
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