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PTPRS (基因名), Receptor-type tyrosine-protein phosphatase S (蛋白名), ptprs_chick.
产品名称:

Chicken PTPRS/ Receptor-type tyrosine-protein phosphatase S ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Chick receptor tyrosine phosphatase alpha, CRYP alpha, R-PTP-S

检测方法:
ELISA
特异性:
Natural and recombinant chicken Receptor-type tyrosine-protein phosphatase S
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Chicken PTPRS ELISA Kit
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Chicken PTPRS ELISA Kit
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通用注释


亚单元:
Homodimer (PubMed:17178832). Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK1 and NTRK3, but does not form detectable complexes with NTRK2 (PubMed:17967490, PubMed:25385546). Interacts (via extracellular domain) with the heparan sulfate proteoglycans AGRN and COL18A1 (PubMed:11865065).


功能:
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:11865065, PubMed:17178832). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (By similarity). Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:17967490). Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:17967490). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (PubMed:17967490). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell projection Axon Perikaryon Cytoplasmic vesicle Secretory vesicle Synaptic vesicle membrane Cell junction Synapse Synaptosome Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Detected along neurites and at axon growth cones.


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