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Bbs9 (基因名), Protein PTHB1 (蛋白名), pthb1_mouse.
产品名称:

Mouse Bbs9/ Protein PTHB1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Bardet-Biedl syndrome 9 protein homolog, Parathyroid hormone-responsive B1 gene protein homolog, Pthb1

检测方法:
ELISA
特异性:
Natural and recombinant mouse Protein PTHB1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Bbs9 ELISA Kit
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Mouse Bbs9 ELISA Kit
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通用注释


亚单元:
Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts with LZTL1; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.


功能:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.


亚细胞位置:
Cell projection Cilium membrane Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriolar satellite


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