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FXYD1 (基因名), Phospholemman (蛋白名), plm_pig.
产品名称:

Pig FXYD1/ Phospholemman ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

FXYD domain-containing ion transport regulator 1, Sodium/potassium-transporting ATPase subunit FXYD1, PLM

检测方法:
ELISA
特异性:
Natural and recombinant pig Phospholemman
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Pig FXYD1 ELISA Kit
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Pig FXYD1 ELISA Kit
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通用注释


亚单元:
Homotetramer (By similarity). Monomer (By similarity). Regulatory subunit of the sodium/potassium-transporting ATPase (NKA) which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit (PubMed:15563542). The monomeric form associates with NKA while the oligomeric form does not (By similarity). Interacts with the catalytic alpha-1 subunit ATP1A1 (PubMed:15563542). Also interacts with the catalytic alpha-2 and alpha-3 subunits ATP1A2 and ATP1A3 (By similarity). Very little interaction with ATP1A1, ATP1A2 or ATP1A3 when phosphorylated at Ser-83 (By similarity). Interacts with the non-catalytic beta-1 subunit ATP1B1 (By similarity). Oxidative stress decreases interaction with ATP1A1 but increases interaction with ATP1B1 (By similarity).


功能:
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone.


亚细胞位置:
Cell membrane Sarcolemma Single-pass type I membrane protein Apical cell membrane Single-pass type I membrane protein Membrane Caveola Cell membrane Sarcolemma T-tubule Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks.


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