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PARP1 (基因名), Poly [ADP-ribose] polymerase 1 (蛋白名), parp1_chick.
产品名称:

Chicken PARP1/ Poly [ADP-ribose] polymerase 1 ELISA Kit
多聚二磷酸腺苷核糖聚合酶1

货号:

E0947c

商标:
EIAab®
监管等级:
别名:

ADP-ribosyltransferase diphtheria toxin-like 1, DNA ADP-ribosyltransferase PARP1, NAD(+) ADP-ribosyltransferase 1, Poly[ADP-ribose] synthase 1, Protein poly-ADP-ribosyltransferase PARP1, ARTD1, ADPRT 1, PARP-1, ADPRT

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/ml
灵敏度:
0.085ng/ml
特异性:
Natural and recombinant chicken Poly [ADP-ribose] polymerase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Epigenetics
Chicken PARP1 ELISA Kit
规格 & 价格: cart
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Chicken PARP1 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homodimer.


功能:
Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity. Probably also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1. Involved in the base excision repair (BER) pathway by catalyzing the poly-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively.


亚细胞位置:
Nucleus Nucleus Nucleolus Chromosome Localizes to sites of DNA damage.


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