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Nlgn2 (基因名), Neuroligin-2 (蛋白名), nlgn2_rat.
产品名称:

Rat Nlgn2/ Neuroligin-2 ELISA Kit
Neuroligin-2

货号:

E12019r

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant rat Neuroligin-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Nlgn2 ELISA Kit
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Rat Nlgn2 ELISA Kit
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亚单元:
Interacts with NRXN1, NRXN2 and NRXN3 (PubMed:8576240, PubMed:18334216, PubMed:20624592). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity). Interacts with PATJ (PubMed:9647694). Interacts with GPHN (PubMed:19755106). Interacts with MDGA1 and MDGA2 (PubMed:23248271). Found in a complex with MAGI2 and IGSF9B, where it interacts with MAGI2 (via WW 1, WW 2 and PDZ 2 domains) (PubMed:23751499).


功能:
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell junction Synapse Postsynaptic cell membrane Cell junction Synapse Presynaptic cell membrane Detected at presynaptic membranes in retina, and at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes.


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