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NFATC1 (基因名), Nuclear factor of activated T-cells, cytoplasmic 1 (蛋白名), nfac1_pig.
产品名称:

Pig NFATC1/ Nuclear factor of activated T-cells, cytoplasmic 1 ELISA Kit
活化t细胞核因子,细胞质1

货号:

E1519p

商标:
EIAab®
监管等级:
别名:

NFAT transcription complex cytosolic component, NFATmac, NF-ATc, NF-ATc1, NFAT2, NFATC

检测方法:
ELISA
特异性:
Natural and recombinant pig Nuclear factor of activated T-cells, cytoplasmic 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Pig NFATC1 ELISA Kit
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Pig NFATC1 ELISA Kit
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通用注释


亚单元:
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers.


功能:
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function.


亚细胞位置:
Cytoplasm Nucleus Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Nuclear translocation OF NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11.


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