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Neil1 (基因名), Endonuclease 8-like 1 (蛋白名), neil1_mouse.
产品名称:

Mouse Neil1/ Endonuclease 8-like 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

DNA glycosylase/AP lyase Neil1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Endonuclease VIII-like 1, Nei homolog 1, Nei-like protein 1, NEH1, Nei1

检测方法:
ELISA
特异性:
Natural and recombinant mouse Endonuclease 8-like 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Neil1 ELISA Kit
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Mouse Neil1 ELISA Kit
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通用注释


亚单元:
N/A


功能:
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.


亚细胞位置:
Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Nucleus Chromosome During mitosis, associates with centrosomes and condensed chromatin.


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