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Nckap1l (基因名), Nck-associated protein 1-like (蛋白名), nckpl_mouse.
产品名称:

Mouse Nckap1l/ Nck-associated protein 1-like ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Hematopoietic protein 1, Hem1

检测方法:
ELISA
特异性:
Natural and recombinant mouse Nck-associated protein 1-like
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Nckap1l ELISA Kit
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Mouse Nckap1l ELISA Kit
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亚单元:
N/A


功能:
Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages (PubMed:19015308, PubMed:23424621). Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization (PubMed:23424621). Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (PubMed:19015308). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Also involved in mechanisms WAVE independent to regulate myosin and actin polymerization during neutrophil chemotaxis.


亚细胞位置:
Membrane Single-pass membrane protein Cytoplasm Localizes to the leading edge of polarized neutrophils.


该产品尚未在任何出版物中被引用。
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