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NLRP1 (基因名), NACHT, LRR and PYD domains-containing protein 1 (蛋白名), nalp1_human.
产品名称:

Human NLRP1/ NACHT, LRR and PYD domains-containing protein 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain, CARD7, DEFCAP, KIAA0926, NAC, NALP1

检测方法:
ELISA
特异性:
Natural and recombinant human NACHT, LRR and PYD domains-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human NLRP1 ELISA Kit
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Human NLRP1 ELISA Kit
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亚单元:
Interacts strongly with caspase-2, weakly with caspase-9 and with APAF1 in a cytochrome c-inducible way, leading to the formation of an apoptosome. This interaction may be ATP-dependent. Part of the NALP1 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18. The complex is activated by bacterial muramyl dipeptide which triggers ATP-binding and oligomerization of NALP1.


功能:
Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP.


亚细胞位置:
Cytoplasm Nucleus


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