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LARP1 (基因名), La-related protein 1 (蛋白名), larp1_human.
产品名称:

Human LARP1/ La-related protein 1 ELISA Kit

货号:

E2849h

商标:
EIAab®
监管等级:
别名:

La ribonucleoprotein domain family member 1, KIAA0731, LARP

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.125ng/mL
特异性:
Natural and recombinant human La-related protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Epigenetics
Human LARP1 ELISA Kit
规格 & 价格: cart
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Human LARP1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with PABPC1/PABP (PubMed:20430826, PubMed:24532714, PubMed:25940091). Associates with the mTORC1 complex via interaction with RPTOR (PubMed:25940091). Interacts with EIF4E (PubMed:20430826). Found in a complex with PABPC1 and RYDEN (PubMed:26735137).


功能:
RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and several components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669). Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).


亚细胞位置:
Cytoplasm Cytoplasmic granule Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.


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