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Krt17 (基因名), Keratin, type I cytoskeletal 17 (蛋白名), k1c17_rat.
产品名称:

Rat Krt17/ Keratin, type I cytoskeletal 17 ELISA Kit
角蛋白,I型细胞骨架

货号:

E1822r

商标:
EIAab®
监管等级:
别名:

Cytokeratin-17, Keratin-17, Type I keratin Ka17, CK-17, K17, Ka17

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
36pg/mL
特异性:
Natural and recombinant rat Keratin, type I cytoskeletal 17
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat Krt17 ELISA Kit
规格 & 价格: cart
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Rat Krt17 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers (KRT6A or KRT6B). Interacts with TRADD and SFN.


功能:
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.


亚细胞位置:
Cytoplasm


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