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Mapk8ip3 (基因名), C-Jun-amino-terminal kinase-interacting protein 3 (蛋白名), jip3_mouse.
产品名称:

Mouse Mapk8ip3/ C-Jun-amino-terminal kinase-interacting protein 3 ELISA Kit

货号:

E2886m

商标:
EIAab®
监管等级:
别名:

JNK MAP kinase scaffold protein 3, JNK/SAPK-associated protein 1, Mitogen-activated protein kinase 8-interacting protein 3, Sunday driver 2, JSAP1, JIP-3, Jip3, Jsap1, Syd2

检测方法:
ELISA
特异性:
Natural and recombinant mouse C-Jun-amino-terminal kinase-interacting protein 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Mapk8ip3 ELISA Kit
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Mouse Mapk8ip3 ELISA Kit
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通用注释


亚单元:
Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation.


功能:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.


亚细胞位置:
Cytoplasm Golgi apparatus Cytoplasmic vesicle Cell projection Growth cone Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells.


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