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ITGAV (基因名), Integrin alpha-V (蛋白名), itav_chick.
产品名称:

Chicken ITGAV/ Integrin alpha-V ELISA Kit
整合素alpha-V

货号:

E0271c

商标:
EIAab®
监管等级:
别名:

Vitronectin receptor subunit alpha

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.78-50ng/ml
灵敏度:
0.22ng/ml
特异性:
Natural and recombinant chicken Integrin alpha-V
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Chicken ITGAV ELISA Kit
规格 & 价格: cart
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Chicken ITGAV ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.


功能:
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1.


亚细胞位置:
Membrane Single-pass type I membrane protein Cell junction Focal adhesion


该产品尚未在任何出版物中被引用。
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