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Ccdc36 (基因名), Interactor of HORMAD1 protein 1 (蛋白名), iho1_mouse.
产品名称:

Mouse Ccdc36/ Interactor of HORMAD1 protein 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Coiled-coil domain-containing protein 36, Iho1

检测方法:
ELISA
特异性:
Natural and recombinant mouse Interactor of HORMAD1 protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Ccdc36 ELISA Kit
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Mouse Ccdc36 ELISA Kit
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通用注释


亚单元:
Interacts with HORMAD1 (PubMed:27723721). Interacts with REC114 (PubMed:27723721). Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4 (PubMed:27723721).


功能:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:27723721). Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance (PubMed:27723721).


亚细胞位置:
Chromosome Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:27723721). Appears on chromatin during preleptotene, when pre-meiotic replication occurs and axes have not yet developed (PubMed:27723721). Remains associated with unsynapsed axesn zygotene, when axes elongate and synapsis begins but disappears from synapsed axes (PubMed:27723721). Localization diverges in the two sexes beyond zygotene (PubMed:27723721). In spermatocytes, synapsis between the largely non-homologous X and Y chromosomes is mostly constrained to their short pseudoautosomal regions (PARs) (PubMed:27723721). At the zygotene-to-pachytene transition, high levels remain on unsynapsed sex chromosome axes but also on PARs (PubMed:27723721). However, by early pachytene disappears from both the synapsed and unsynapsed regions of sex chromosomes (PubMed:27723721). Reaccumulates on unsynapsed axes of sex chromosomes in mid-late pachytene and on desynapsing autosome axes in diplotene, but disappears from chromatin concomitant with axis disassembly after diplotene (PubMed:27723721). In oocytes, disappears from axes after all chromosomes synapsed and is undetectable on chromatin beyond zygotene (PubMed:27723721). Ovarian levels also dramatically decrease as oocytes progress to late prophase (PubMed:27723721). HORMAD1 is required for robust accumulation on chromatin and unsynapsed axes, suggesting that HORMAD1 recruits IHO1/CCDC36 to unsynapsed axes (PubMed:27723721).


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