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Gldn (基因名), Gliomedin (蛋白名), gldn_mouse.
产品名称:

Mouse Gldn/ Gliomedin ELISA Kit

货号:

E13730m

商标:
EIAab®
监管等级:
别名:

Cancer-related gene liver 2 protein, CRG-L2, Crgl2

检测方法:
ELISA
特异性:
Natural and recombinant mouse Gliomedin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Gldn ELISA Kit
规格 & 价格: cart
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Mouse Gldn ELISA Kit
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通用注释


亚单元:
Homotrimer (via collagen-like domains) (PubMed:17293346). Interacts with NRCAM and NFACS/neurofascin (PubMed:16039564, PubMed:20188654). Interaction with glial NRCAM enhances interaction with axonal NFACS (PubMed:20188654). Interacts with MYOC (PubMed:23897819).


功能:
Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:20188654). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:20188654). Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088).


亚细胞位置:
Gliomedin shedded ectodomain Secreted Secreted Extracellular space Extracellular matrix Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:17293346). The gliomedin shedded ectodomain localizes to the nodes of Ranvier (By similarity).


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