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GBP5 (基因名), Guanylate-binding protein 5 (蛋白名), gbp5_human.
产品名称:

Human GBP5/ Guanylate-binding protein 5 ELISA Kit

货号:

E11163h

商标:
EIAab®
监管等级:
别名:

GBP-TA antigen, GTP-binding protein 5, Guanine nucleotide-binding protein 5, GBP-5, UNQ2427/PRO4987

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.058ng/mL
特异性:
Natural and recombinant human Guanylate-binding protein 5
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human GBP5 ELISA Kit
规格 & 价格: cart
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Human GBP5 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homodimer (PubMed:21151871). Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (PubMed:21151871). Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric (PubMed:20180847). Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP (PubMed:20180847). Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).


功能:
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).


亚细胞位置:
Cytoplasm Golgi apparatus membrane Lipid-anchor


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