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FZD6 (基因名), Frizzled-6 (蛋白名), fzd6_canlf.
产品名称:

Dog FZD6/ Frizzled-6 ELISA Kit

货号:

E11114d

商标:
EIAab®
监管等级:
别名:

Fz-6

检测方法:
ELISA
特异性:
Natural and recombinant dog Frizzled-6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Dog FZD6 ELISA Kit
规格 & 价格: cart
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Dog FZD6 ELISA Kit
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亚单元:
N/A


功能:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.


亚细胞位置:
Membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell surface Apical cell membrane Multi-pass membrane protein Cytoplasmic vesicle membrane Multi-pass membrane protein Colocalizes with FZD3 at the apical face of cells (By similarity).


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