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FKBP6 (基因名), Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (蛋白名), fkbp6_horse.
产品名称:

Horse FKBP6/ Inactive peptidyl-prolyl cis-trans isomerase FKBP6 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

36 kDa FK506-binding protein, FK506-binding protein 6, Immunophilin FKBP36, FKBP-6, Inactive PPIase FKBP6, FKBP36

检测方法:
ELISA
特异性:
Natural and recombinant horse Inactive peptidyl-prolyl cis-trans isomerase FKBP6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Horse FKBP6 ELISA Kit
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Horse FKBP6 ELISA Kit
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亚单元:
Interacts with HSP72/HSPA2 and CLTC. Interacts with GAPDH; leading to inhibit GAPDH catalytic activity. Interacts (via TPR repeats) with HSP90.


功能:
Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes.


亚细胞位置:
Cytoplasm Cytosol Nucleus Chromosome Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).


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