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FGFR1 (基因名), Fibroblast growth factor receptor 1 (蛋白名), fgfr1_chick.
产品名称:

Chicken FGFR1/ Fibroblast growth factor receptor 1 ELISA Kit
成纤维生长因子受体1

货号:

E0074c

商标:
EIAab®
监管等级:
别名:

Basic fibroblast growth factor receptor 1, Tyrosine kinase receptor CEK1, FGFR-1, CEK1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
39pg/mL
特异性:
Natural and recombinant chicken Fibroblast growth factor receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Chicken FGFR1 ELISA Kit
规格 & 价格: cart
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Chicken FGFR1 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Monomer. Homodimer after ligand binding.


功能:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Nucleus Cytoplasm Cytosol Cytoplasmic vesicle After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity).


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