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Ero1b (基因名), ERO1-like protein beta (蛋白名), ero1b_mouse.
产品名称:

Mouse Ero1b/ ERO1-like protein beta ELISA Kit
ERO1-like蛋白β

货号:

E6182m

商标:
EIAab®
监管等级:
别名:

Endoplasmic reticulum oxidoreductase beta, Endoplasmic reticulum oxidoreductin-1-like protein B, Oxidoreductin-1-L-beta, ERO1-L-beta, Ero1lb

检测方法:
ELISA
特异性:
Natural and recombinant mouse ERO1-like protein beta
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Ero1b ELISA Kit
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Mouse Ero1b ELISA Kit
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通用注释


亚单元:
Homodimer; disulfide-linked (By similarity). Heterodimer with ERO1A; disulfide-linked (By similarity). Also detected as monomer. Homodimers may be somewhat less active than monomers. The abundance of monomers and homodimers may be tissue-specific. Interacts with P4HB (By similarity). Interacts with ERP44.


功能:
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity). Involved in oxidative proinsulin folding in pancreatic cells, hence required for glucose homeostasis in vivo.


亚细胞位置:
Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side The association with ERP44 may be essential for its retention in the endoplasmic reticulum.


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