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Ephb3 (基因名), Ephrin type-B receptor 3 (蛋白名), ephb3_mouse.
产品名称:

Mouse Ephb3/ Ephrin type-B receptor 3 ELISA Kit

货号:

E10777m

商标:
EIAab®
监管等级:
别名:

Developmental kinase 5, Tyrosine-protein kinase receptor SEK-4, mDK-5, Etk2, Mdk5, Sek4

检测方法:
ELISA
特异性:
Natural and recombinant mouse Ephrin type-B receptor 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Ephb3 ELISA Kit
规格 & 价格: cart
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Mouse Ephb3 ELISA Kit
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通用注释


亚单元:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.


功能:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell projection Dendrite


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