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Disc1 (基因名), Disrupted in schizophrenia 1 homolog (蛋白名), disc1_mouse.
产品名称:

Mouse Disc1/ Disrupted in schizophrenia 1 homolog ELISA Kit

货号:

E9602m

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant mouse Disrupted in schizophrenia 1 homolog
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Neurosciences
Mouse Disc1 ELISA Kit
规格 & 价格: cart
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Mouse Disc1 ELISA Kit
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通用注释


亚单元:
Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts (via C-terminal) with PCNT. Interacts with CHCHD6 (By similarity). Interacts with NDEL1 (PubMed:14962739). Interacts with CCDC88A (via C-terminus); the interaction is direct (PubMed:19778506). Interacts with GSK3B (PubMed:19303846). Interacts with CCDC141 (PubMed:20956536).


功能:
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.


亚细胞位置:
Cytoplasm Cytoplasm Cytoskeleton Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria.


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