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CUBN (基因名), Cubilin (蛋白名), cubn_canfa.
产品名称:

Dog CUBN/ Cubilin ELISA Kit
Cubilin蛋白

货号:

E9664d

商标:
EIAab®
监管等级:
检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.097ng/mL
特异性:
Natural and recombinant dog Cubilin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Metabolism
Dog CUBN ELISA Kit
规格 & 价格: cart
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Dog CUBN ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

97-108%

108-119%

81-90%

97-108%

EDTA plasma(n=5)

103-112%

102-114%

88-98%

85-94%

heparin plasma(n=5)

107-116%

 

96-108%

84-94%

110-118%

 

通用注释


亚单元:
Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Component of the cubam complex composed of CUBN and AMN. The cubam complex can oligomerize and form cubam trimers. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1.


功能:
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.


亚细胞位置:
Endosome membrane Peripheral membrane protein Lysosome membrane Peripheral membrane protein Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells.


该产品尚未在任何出版物中被引用。
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