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Csrp3 (基因名), Cysteine and glycine-rich protein 3 (蛋白名), csrp3_rat.
产品名称:

Rat Csrp3/ Cysteine and glycine-rich protein 3 ELISA Kit
富含半胱氨酸和甘氨酸的蛋白质

货号:

E15404r

商标:
EIAab®
监管等级:
别名:

Cysteine-rich protein 3, LIM domain protein, cardiac, Muscle LIM protein, CRP3, Clp, Mlp

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.063ng/mL
特异性:
Natural and recombinant rat Cysteine and glycine-rich protein 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat Csrp3 ELISA Kit
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Rat Csrp3 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Self-associates. Oligomeric in the cytoplasm and monomeric in the nucleus (PubMed:16963613). Homooligomers preferentially form along the actin cytoskeleton (By similarity). Interacts with TCAP, ACTN2 and NRAP (By similarity). Interacts with LDHD, SPTB, MYOD1, MYOG, MYF6. Interacts with GLRX3 (via C-terminus); GLRX3 and calcineurin compete for interaction with CSRP3 (PubMed:9234731, PubMed:10751147, PubMed:12127981, PubMed:18258855). Interacts with CFL2; the stoichiometry influences F-actin depolymerization and possibly two molecules of CFL2 can interact with one molecule of CSRP3 resulting in the highest functional impact; the interaction is stronger with phosphorylated CFL2.


功能:
Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (PubMed:7954791, PubMed:9234731). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling.


亚细胞位置:
Nucleus Cytoplasm Cytoplasm Cytoskeleton Cytoplasm Myofibril Sarcomere Z line Cytoplasm Myofibril Sarcomere Nucleocytoplasmic shuttling protein (PubMed:19376126). Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity).


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