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CCNT1 (基因名), Cyclin-T1 (蛋白名), ccnt1_horse.
产品名称:

Horse CCNT1/ Cyclin-T1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

CycT1

检测方法:
ELISA
特异性:
Natural and recombinant horse Cyclin-T1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Horse CCNT1 ELISA Kit
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Horse CCNT1 ELISA Kit
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产品说明书
在线询价


通用注释


亚单元:
Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31 (By similarity). Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin (PubMed:10964778). Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, probably to target chromatin binding. Interacts with MDFIC. Interacts with HSF1. Interacts with HTATSF1. Interacts with AFF4.


功能:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。
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