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CAV1 (基因名), Caveolin-1 (蛋白名), cav1_horse.
产品名称:

Horse CAV1/ Caveolin-1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant horse Caveolin-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Horse CAV1 ELISA Kit
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Horse CAV1 ELISA Kit
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通用注释


亚单元:
Homooligomer (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Interacts with PACSIN2. Interacts with BMX, BTK, CTNNB1, CDH1, GLIPR2, JUP, NOSTRIN, SNAP25 and STX1A. Interacts with SLC7A9. Interacts with TGFBR1.


功能:
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.


亚细胞位置:
Golgi apparatus membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Membrane Caveola Peripheral membrane protein Membrane raft Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity).


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