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Brca2 (基因名), Breast cancer type 2 susceptibility protein homolog (蛋白名), brca2_mouse.
产品名称:

Mouse Brca2/ Breast cancer type 2 susceptibility protein homolog ELISA Kit
乳腺癌2型易感蛋白

货号:

E1364m

商标:
EIAab®
监管等级:
别名:

Fanconi anemia group D1 protein homolog, Fancd1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/ml
灵敏度:
39.4pg/mL
特异性:
Natural and recombinant mouse Breast cancer type 2 susceptibility protein homolog
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Brca2 ELISA Kit
规格 & 价格: cart
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Mouse Brca2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SEM1.


功能:
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination.


亚细胞位置:
Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Nucleus


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