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BIRC6 (基因名), Baculoviral IAP repeat-containing protein 6 (蛋白名), birc6_human.
产品名称:

Human BIRC6/ Baculoviral IAP repeat-containing protein 6 ELISA Kit
杆状病毒IAP含重复蛋白6

货号:

E0308h

商标:
EIAab®
监管等级:
别名:

BIR repeat-containing ubiquitin-conjugating enzyme, RING-type E3 ubiquitin transferase BIRC6, Ubiquitin-conjugating BIR domain enzyme apollon, BRUCE, APOLLON, KIAA1289

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.056ng/mL
特异性:
Natural and recombinant human Baculoviral IAP repeat-containing protein 6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cell Biology
Human BIRC6 ELISA Kit
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Human BIRC6 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤3.3%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤7.2%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

88

82-94

Plasma

90

84-96

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

102-112%

99-108%

90-100%

104-114%

EDTA plasma(n=5)

94-104%

99-109%

104-114%

110-120%

heparin plasma(n=5)

91-100%

 

102-111%

111-111%

102-111%

 

通用注释


亚单元:
Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8.


功能:
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.


亚细胞位置:
Golgi apparatus Trans-Golgi network membrane Midbody Endosome Cytoplasm Cytoskeleton Spindle pole Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.


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