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BBIP1 (基因名), BBSome-interacting protein 1 (蛋白名), bbip1_human.
产品名称:

Human BBIP1/ BBSome-interacting protein 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

BBSome-interacting protein of 10 kDa, BBIP10, NCRNA00081

检测方法:
ELISA
特异性:
Natural and recombinant human BBSome-interacting protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human BBIP1 ELISA Kit
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Human BBIP1 ELISA Kit
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通用注释


亚单元:
Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. Interacts with HDAC6.


功能:
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for primary cilia assembly and BBSome stability. Regulates cytoplasmic microtubule stability and acetylation.


亚细胞位置:
Cell projection Cilium Cytoplasm Localizes inside the primary cilium but not at centriolar satellites.


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