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Baz1b (基因名), Tyrosine-protein kinase BAZ1B (蛋白名), baz1b_mouse.
产品名称:

Mouse Baz1b/ Tyrosine-protein kinase BAZ1B ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor homolog, Williams-Beuren syndrome chromosomal region 9 protein homolog, Wbscr9, Wstf

检测方法:
ELISA
特异性:
Natural and recombinant mouse Tyrosine-protein kinase BAZ1B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Baz1b ELISA Kit
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Mouse Baz1b ELISA Kit
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通用注释


亚单元:
Interacts with MYO1C (By similarity). Interacts with CDT1. Interacts with SMARCA5/SNF2H; the interaction is direct and forms the WICH complex. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with VDR; in a ligand-dependent manner. Interacts with PCNA; the interaction is direct.


功能:
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.


亚细胞位置:
Nucleus Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA (By similarity).


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