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Bag1 (基因名), BAG family molecular chaperone regulator 1 (蛋白名), bag1_mouse.
产品名称:

Mouse Bag1/ BAG family molecular chaperone regulator 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Bcl-2-associated athanogene 1, BAG-1

检测方法:
ELISA
特异性:
Natural and recombinant mouse BAG family molecular chaperone regulator 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Mouse Bag1 ELISA Kit
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Mouse Bag1 ELISA Kit
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通用注释


亚单元:
Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Interacts with SIAH1, HSPA8 (via NBD), HSPA1A (via NBD) and HSPA1B (via NBD) (By similarity). Interacts with SIAH2 (PubMed:11257006).


功能:
Co-chaperone for HSP70 and HSC70 chaperone proteins (PubMed:9873016). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.


亚细胞位置:
Isoform 2 Cytoplasm


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