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Snai2 (基因名), Zinc finger protein SNAI2 (蛋白名), SNAI2_RAT.
产品名称:

Rat Snai2/ Zinc finger protein SNAI2 ELISA Kit
锌指蛋白SNAI2

货号:

E2412r

商标:
EIAab®
监管等级:
别名:

Neural crest transcription factor Slug, Protein snail homolog 2, Slug, Slugh

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.087ng/mL
特异性:
Natural and recombinant rat Zinc finger protein SNAI2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Rat Snai2 ELISA Kit
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Rat Snai2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1 and TNPO1. May interact (via zinc fingers) with IPO7.


功能:
Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.


亚细胞位置:
Nucleus Cytoplasm Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions (By similarity).


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