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Rtn4 (基因名), Reticulon-4 (蛋白名), RTN4_RAT.
产品名称:

Rat Rtn4/ Reticulon-4 ELISA Kit
网状蛋白4

货号:

E12266r

商标:
EIAab®
监管等级:
别名:

Foocen, Glut4 vesicle 20 kDa protein, Neurite outgrowth inhibitor, Nogo protein, Nogo

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
40.6pg/mL
特异性:
Natural and recombinant rat Reticulon-4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Epigenetics
Rat Rtn4 ELISA Kit
规格 & 价格: cart
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Rat Rtn4 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Isoform 2 binds to NGBR and RTN3. Isoform 2 and isoform 3 interact ith BACE1 and BACE2 (By similarity). Interacts with RTN4IP1 (By similarity). Interacts in trans with CNTNAP1. Interacts with ATL1. Interacts with TMEM170A and TMEM33.


功能:
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules. Regulates membrane morphogenesis in the ER by promoting tubular ER production. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. Co-localizes with TMEM33 at the ER sheets.


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