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PSEN1 (基因名), Presenilin-1 (蛋白名), PSN1_CHICK.
产品名称:

Chicken PSEN1/ Presenilin-1 ELISA Kit
Presenilin-1

货号:

E15382c

商标:
EIAab®
监管等级:
别名:

PS-1

检测方法:
ELISA
特异性:
Natural and recombinant chicken Presenilin-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Neurosciences
Chicken PSEN1 ELISA Kit
规格 & 价格: cart
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Chicken PSEN1 ELISA Kit
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通用注释


亚单元:
Homodimer. The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity (By similarity). Predominantly heterodimer of a N-terminal (NTF) and a C-terminal (CTF) endoproteolytical fragment (By similarity). Interacts with CDH2 (PubMed:16046145).


功能:
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins.


亚细胞位置:
Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Cytoplasmic granule Cell membrane Cell projection Axon Cell junction Synapse


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