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Otof (基因名), Otoferlin (蛋白名), OTOF_RAT.
产品名称:

Rat Otof/ Otoferlin ELISA Kit
Otoferlin

货号:

E15538r

商标:
EIAab®
监管等级:
别名:

Fer-1-like protein 2, Fer1l2

检测方法:
ELISA
特异性:
Natural and recombinant rat Otoferlin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Otof ELISA Kit
规格 & 价格: cart
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Rat Otof ELISA Kit
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通用注释


亚单元:
Interacts with SNAP25; the interaction is direct. Interacts with STX1; the interaction is direct. Interacts with RAB8B.


功能:
Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes.


亚细胞位置:
Cytoplasmic vesicle Secretory vesicle Synaptic vesicle membrane Single-pass type II membrane protein Basolateral cell membrane Single-pass type II membrane protein Endoplasmic reticulum membrane Single-pass type II membrane protein Cell membrane Single-pass type II membrane protein Detected at basolateral cell membrane with synaptic vesicles surrounding the ribbon and at the presynaptic plasma membrane in the inner hair cells (IHCs). Colocalizes with GPR25 and RAB8B in inner hair cells (By similarity).


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