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MTM1 (基因名), Myotubularin (蛋白名), MTM1_BOVIN.
产品名称:

Bovine MTM1/ Myotubularin ELISA Kit
Myotubularin

货号:

E15150b

商标:
EIAab®
监管等级:
别名:

Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase

检测方法:
ELISA
特异性:
Natural and recombinant bovine Myotubularin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cardiovascular
Bovine MTM1 ELISA Kit
规格 & 价格: cart
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Bovine MTM1 ELISA Kit
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通用注释


亚单元:
Interacts with MTMR12; the interaction modulates MTM1 intracellular localization. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle (By similarity). Interacts with SPEG.


功能:
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.


亚细胞位置:
Cytoplasm Cell membrane Peripheral membrane protein Cell projection Filopodium Cell projection Ruffle Late endosome Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation (By similarity).


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