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Lrrk2 (基因名), Leucine-rich repeat serine/threonine-protein kinase 2 (蛋白名), LRRK2_MOUSE.
产品名称:

Mouse Lrrk2/ Leucine-rich repeat serine/threonine-protein kinase 2 ELISA Kit
富亮氨酸重复序列的丝氨酸/苏氨酸蛋白激酶2

货号:

E1515m

商标:
EIAab®
监管等级:
检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.082ng/mL
特异性:
Natural and recombinant mouse Leucine-rich repeat serine/threonine-protein kinase 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Mouse Lrrk2 ELISA Kit
规格 & 价格: cart
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Mouse Lrrk2 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
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通用注释


亚单元:
Homodimer. Interacts with PARK2, PRDX3 and TPCN2 (By similarity). Interacts with VPS35 and RAB29.


功能:
Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. Has GTPase activity.


亚细胞位置:
Membrane Peripheral membrane protein Cytoplasm Perikaryon Cell projection Axon Cell projection Dendrite Golgi apparatus Endoplasmic reticulum Cytoplasmic vesicle Secretory vesicle Synaptic vesicle membrane Peripheral membrane protein Cytoplasmic side Endosome Lysosome Mitochondrion outer membrane Mitochondrion inner membrane Mitochondrion matrix Localized in the cytoplasm and associated with cellular membrane structures. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of neuronal perikarya and dendritic and axonal processes (By similarity). Predominantly associated with intracytoplasmic vesicular and membranous structures. Predominantly associated with the mitochondrial outer membrane of the mitochondria.


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