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CLDN1 (基因名), Claudin-1 (蛋白名), CLD1_BOVIN.
产品名称:

Bovine CLDN1/ Claudin-1 ELISA Kit
封闭蛋白1

货号:

E9653b

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant bovine Claudin-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Signal Transduction
Bovine CLDN1 ELISA Kit
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Bovine CLDN1 ELISA Kit
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通用注释


亚单元:
Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers (By similarity). Interacts with MPDZ and PATJ.


功能:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.


亚细胞位置:
Cell junction Tight junction Cell membrane Multi-pass membrane protein


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