Human ZC3H8/ Zinc finger CCCH domain-containing protein 8 CLIA Kit
含锌指CCCH结构域蛋白8

货号:

U15467h

商标:

EIAab^®

监管等级:

RUO

别名:

ZC3HDC8

检测方法:

CLIA

特异性:

Natural and recombinant human Zinc finger CCCH domain-containing protein 8

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human ZC3H8 CLIA Kit

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通用注释

亚单元:

Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain).

功能:

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

亚细胞位置:

Nucleus Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

数据库链接

UniGene:

Hs.418416

SMR:

Q8N5P1

STRING:

9606.ENSP00000386488

KEGG:

hsa:84524

Pfam:

PF00642

Uniprot: