Human YES1/ Tyrosine-protein kinase Yes CLIA Kit

货号:

U16072h

商标:

EIAab^®

监管等级:

RUO

别名:

Proto-oncogene c-Yes, p61-Yes, YES

检测方法:

CLIA

特异性:

Natural and recombinant human Tyrosine-protein kinase Yes

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human YES1 CLIA Kit

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通用注释

亚单元:

Interacts with YAP1 and CSF1R (By similarity). Interacts with CTNND1; this interaction allows YES1-mediated activation of FYN and FER and subsequent phosphorylation of CTNND1 (By similarity). Interacts with FASLG.

功能:

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

亚细胞位置:

Cell membrane Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytosol Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.

数据库链接

UniGene:

Hs.194148

SMR:

P07947

STRING:

9606.ENSP00000324740

KEGG:

hsa:7525

MIM:

164880

Pfam: