XRCC3 (基因名), DNA repair protein XRCC3 (蛋白名), xrcc3_bovin.
产品名称:
Bovine XRCC3/ DNA repair protein XRCC3 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
X-ray repair cross-complementing protein 3
检测方法:
CLIA
特异性:
Natural and recombinant bovine DNA repair protein XRCC3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
研究领域:
-
通用注释
亚单元:
Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.
功能:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
亚细胞位置:
Nucleus
Cytoplasm
Cytoplasm
Perinuclear region
Mitochondrion matrix
Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
您可能感兴趣
该产品尚未在任何出版物中被引用。
反馈墙
评论数 : 0
所有用户
所有用户
默认排序
默认排序
最近
早期
目前还没有评论。
通知
规格
数量
单价 (¥)
小计 1 (¥)
小计 2:
¥
规格
数量
单价 (¥)