Rat Wnk4/ Serine/threonine-protein kinase WNK4 CLIA Kit

货号:

U12933r

商标:

EIAab^®

监管等级:

RUO

别名:

Protein kinase lysine-deficient 4, Protein kinase with no lysine 4, Prkwnk4

检测方法:

CLIA

特异性:

Natural and recombinant rat Serine/threonine-protein kinase WNK4

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

关注

Rat Wnk4 CLIA Kit

邮箱 *

消息 *

Please 登录.

产品说明书

在线询价

数据
文献
序列 / 3D
反馈墙 (0)

通用注释

亚单元:

Interacts with the C-terminal region of KCNJ1. Interacts with KLHL3, WNK1 and WNK3.

功能:

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. Phosphorylates NEDD4L.

亚细胞位置:

Cell junction Tight junction Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity).

数据库链接

UniGene:

Rn.228251

STRING:

10116.ENSRNOP00000027804

KEGG:

rno:287715

Pfam:

PF12202

Uniprot:

Q7TPK6

相关产品